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The execution of it is where the beauty is, Counsell said

Model 1 included no adjustments, Model 2 adjusted for age (median-stratified), sex, education, family income to poverty ratio, BMI, and race/ethnicity, Model 3 additionally adjusted for hypertension, drinking status, smoking status, diabetes, and PHQ-9, and Model 4 included all potential covariates

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In 2015, a minimum age of sale for e-cigarettes of 18 was introduced, making it illegal to sell e-cigarettes containing nicotine to under 18s or to purchase them on behalf of under 18s.[24] From 20th May 2016, a regulatory framework for e-cigarettes was introduced in the UK under the EU Tobacco Products Directive (TPD) Article 20.14 The regulations are due to be updated and strengthened following a review in 2023, but the timescale and content of the revised regulations has still to be decided at time of publication of this factsheet